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NEWS
Congratulations to Morgan on her advancement to candidacy!
Morgan is now one step closer to a PhD!
New review by Bess and Josh Dubnau in Annual Review of Neuroscience
The Role of Retrotransposons and Endogenous Retroviruses in Age-Dependent Neurodegenerative Disorders: Annual Review of Neuroscience. Check it out!
Viva Science SA 2024
The Graduate School of Biomedical Sciences held their annual science fair for the community this past April. Jasmine and Annie contributed artwork artwork to the event!
Tau2024 Global Conference in Washington D.C.
The Frost lab attended the Tau2024 Global Conference last week - a fantastic forum for collaborating and discussing important issues in the tau research community. Bess served as co-organizer with Dr. James Rowe. Congrats to Zach Uttke on his travel award. We look forward to applying the insights and important takeaways in our future research!
Congratulations to Dr. Ramirez on a successful defense!
Please join us in congratulating Dr. Ramirez on the successful defense of their dissertation, Bioinformatic Analysis of Retrotransposons in the Context of Tauopathy. Thank you to all who attended, Paul's parents, sister and future brother-in-law. Special thanks to Paul's committee members for their thoughtful input and questions throughout the dissertation process: Dr. Sarah Hopp (committee member) Dr. Bernard Fongang (committee member) Dr. Evelien Bunnik (committee member) D
Congratulations to Dr. Zuniga and her match at UTHSA!
It's Match Week! On Monday, students found out if they matched to their residency - students found out today where they will go. Dr. Zuniga will be completing an Emergency Medicine residency with UT Health San Antonio. We know she will be an exceptional doctor and can't wait to see what she will achieve next. Best of luck! Match Day 2024 at UT Health San Antonio Long School of Medicine
We are excited to announce the results of our AntiRetroviral Therapy for Alzheimer’s Disease (ART-AD) clinical trial!
This is a preprint that has not yet been reviewed. While our results are promising, this is a small trial lacking a placebo control. The study drug (3TC, aka lamivudine) would need to be tested in a large cohort of individuals and compared to a placebo control before we will know if it is an effective therapy for Alzheimer’s disease. ART-AD was an open-label phase 2 clinical trial testing the effects of 3TC in individuals with mild cognitive impairment due to suspected Alzhei
New work from Frost lab MD/PhD student Dr. Gabrielle Zuniga provides new insights into the effects of pathogenic forms of tau on RNA translation
Read the publication on bioRxiv. We have previously shown that RNAs accumulate within nuclear envelope invaginations in tau transgenic Drosophila (and have now seen this in various other model systems of tauopathy as well): https://doi.org/10.1111/acel.12847 Gabbe previously reported that error-containing RNAs are not properly cleared via nonsense-mediated RNA decay in settings of tauopathy, and that such RNAs are translated into protein that also accumulates within nuclear e
Interested in genomics, retrotransposons, structural variation, DNA methylation, dark loci, brain aging or Alzheimer’s disease?
Check out our new Oxford Nanopore Technologies DNA sequencing-based analysis of the aged human brain with and without tau pathology. While lead author Paulino Ramirez set off on this endeavor because we wanted to know if somatic retrotransposition is elevated in human brains harboring pathogenic forms of tau (google “Frost tau retrotransposon” for the backstory), we learned a lot of other stuff along the way. There’s a ton of data in the manuscript – a little something for
"Novel avenues of tau research" published in Alzheimer's & Dementia
This new publication covers recent advances and new discoveries in tau research that were presented at the global Tau 2022 conference. Read the publication here.
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