NEWS

We think that pathogenic forms of tau disrupt the cellular program that maintains terminal differentiation of neurons. We have a new publication related to this idea – this project was led by our first PhD student, Adrian Beckmann: Adrian discovered that tau-induced aberrant activation of Moesin, a crosslinker of the plasma membrane and actin cytoskeleton that is known for its role in cancer and the epithelial-mesenchymal transition (EMT), drives cell cycle activation and con

Annie's artwork will be featured in the upcoming edition of Connective Tissue. Connective Tissue aims to cultivate the arts and humanities at UTHSA - the editorial received 208 submissions, and Annie had TWO pieces selected for inclusion. Her drawing (below) and an original song will be featured in the 2023 edition. We are all feeling artsy by proximity.

Congratulations to Lulu on her "Best Poster Award in the Basic Science" award at the South Texas Alzheimer's Conference! Lulu presented her work on tau-induced Arc overexpression/multimerization as a driver of neurodegeneration.

We are dipping our toes into the world of nuclear mechanics 😊. Frost lab grad student Claira Sohn has discovered that pathogenic forms of tau cause an overall decrease in nuclear tension in cultured neuroblastoma cells: "Pathogenic tau decreases nuclear tension in cultured neurons" Claira became interested in a potential role for tau in nuclear mechanotransduction based on our previous studies showing that pathogenic forms of tau destabilize the lamin nucleoskeleton. To quan

We are pleased to share our recent publication in Science Advances! https://www.science.org/doi/10.1126/sciadv.abq5423 This work was spearheaded by our most recent PhD graduate, Dr. Elizabeth Ochoa.

We are thrilled to announce that Elizabeth Ochoa, Frost lab PhD student, has been selected as the 2022 graduate student recipient of the Joe H. Ward Jr. and Bettie B. Ward Award for Excellence in the Study of the Biology of Aging. This award is based on the originality and creativity of Elizabeth's research and its anticipated benefit to the aging research community. Elizabeth will present her dissertation work at the Barshop Institute Seminar Series on Wednesday, November 9,

We are currently fundraising in support of the Alzheimer's Association Walk to End Alzheimer's. The Alzheimer's Association is raising funds that will allow them to provide 24/7 care and support for patients and caregivers and advance research toward methods of prevention, treatment, and, ultimately, a cure. Please consider going to our Frost Fleet team page to make a donation! #ENDALZ #Walk2EndAlz

Dr. Meghna Chinchankar has joined the Frost lab as a postdoctoral fellow. Dr. Chinchankar earned her Integrated M.Sc. degree in Biotechnology from the University of Pune, India, and her Ph.D. in the Biology of Aging discipline of the Integrated Biomedical Sciences program at UT Heath San Antonio. Her dissertation research in the laboratory of Dr. Alfred Fisher focused on ER-associated proteostasis in a novel long-lived proteasomal mutant of C. elegans. During her time as a gr

We'd like to take a moment to shine the spotlight on the postdocs currently training in the Frost lab. We are proud of everything they have achieved and their positive impact as mentors! Thank you for all of your contributions and advances you have made for our scientific endeavors.