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PREPRINTS

  1. ​Beckmann A, Ramirez P, Gamez M, Ray WJ, Frost (2021) Pathogenic tau disrupts the cellular program that maintains neuronal identity. bioRxiv,     https://www.biorxiv.org/content10.1101/2021.03.05.434166v1

FROST LAB/FROST ORIGINALS

  1. Beckmann A, Ramirez P, Games M, Bieniek KF, Ray WJ, Frost B (2023) Moesin is an effector of tau-induced actin over stabilization, cell cycle activation, and neurotoxicity in Alzheimer's disease. iScience, 26(3): 106152. https://doi.org/10.1016/j.isci.2023.106152

  2. Sohn C, Ma J, Ray WJ, Frost B (2023) Pathogenic tau decreases nuclear tension in cultured neurons. Frontiers in Aging, 4:1058968. https://doi.org/10.3389/fragi.2023.1058968

  3. Ochoa E, Ramirez P, Gonzalez E, De Mange J, Ray William J, Bieniek Kevin J, Frost B (2023) Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation. Science Advances, Online ahead of print. https://www.science.org/doi/10.1126/sciadv.abq5423

  4. Levy S, Zuniga G, Gonzalez E, Butler D, Temple S, Frost B (2022) TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy. Cell Reports Methods, 2(9):100292. https://doi.org/10.1016/j.crmeth.2022.100292

  5. Schulz L, Ramirez P, Lemieux A, Gonzalez E, Thomson T, Frost B (2022) Tau-induced elevation of the activity-regulated cytoskeleton associated protein Arc1 causally mediates neurodegeneration in the adult Drosophila brain. Neuroscience, in press. PMID: 35487302

  6. Zuniga G, Levy S, Ramirez P, De Mange J, Gonzalez E, Gamez M, Frost B (2022) Tau-induced deficits in nonsense-mediated mRNA decay contribute to neurodegeneration. Alzheimer's & Dementia. 19(2): 405-420. PMID: 35416419

  7. Ramirez P, Sun W, Zuniga G, Ochoa E, DeVos S, Hyman B, Chiu G, Roy ER, Orr M, Bugga-Prevot V, Ray WJ, Frost B (2022) Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system. Progress in Neurobiology, 208: 102181. PMID: 34670118.

  8. Mahoney R, Ochoa E, Ramirez P, Miller HE, Beckmann A, Zuniga G, Dobrowolski R, Frost B (2020) Pathogenic tau causes a toxic depletion of nuclear calcium. Cell Reports, 32(2):107900. PMCID: PMC7428851.

  9. Ochoa E, Zuniga G, Sun W, Frost B (2020) Awakening the dark side: retrotransposon activation in neurodegenerative disorders. Current Opinion in Neurobiology, 61:65-72. PMID: 32092528.

  10. Cornelison G, Levy S, Jenson T, Frost B (2019) Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila. Aging Cell, 18(1):el2847 PMCID: PMC6351838.

  11. Sun W, Samimi H, Gamez M, Zare H, Frost B (2018) Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies. Nature Neuroscience, 21(8): 1038-1048. PMCID: PMC6095477.

  12. Orr ME, Sullivan C, Frost B (2017) A brief overview of tauopathy: Causes, consequences and therapeutic strategies. Trends in Pharmacological Sciences, 38(7): 637-648. PMCID: PM5476494.

  13. Frost B (2016) Alzheimer's disease: An acquired neurodegenerative laminopathy. Nucleus, 7(3):275-83). PMCID: PMC4991240. 

  14. Frost B, Bardai FH, Feany MB (2016) Lamin dysfunction mediates neurodegeneration in tauopathies. Current Biology, 11:26(1): 129-36. PMID: 26725200.

  15. Frost B, Gotz J, Feany MB (2015) Connecting the dots between tau dysfunction and neurodegeneration. Trends in Cell Biology, 25(1):46-53). PMCID: PMC4275400.

  16. Frost B, Hemberg M, Lewis J, Feany MB (2014) Tau promotes neurodegeneration through global chromatin relaxation. Nature Neuroscience, 17(3): 357-66. PMCID: PMC4012297.

  17. Frost B, Diamond MI (2010) Prion-like mechanisms in neurodegenerative diseases. Nature Reviews Neuroscience, 11(3)155-9. PMCID: PMC3648341.

  18. Frost B, Diamond MI (2009) The expanding realm of prion phenomena in neurodegenerative disease. Prion, 3(2)74-7. PMCID: PMC2712602.

  19. Frost B, Jacks RL, Diamond MI (2009) Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem. 284(19):12845-12852. PMCID PMC2676015.

  20. Frost B, Ollesch J, Wille H, Diamond MI (2009) Conformational diversity of wild-type tau fibrils specified by templated confirmation change. J Biol Chem. 284(6):3546-3551. PMCID: PMC2635036.

COLLABORATIONS

  1. Miller HE, Montemayor D, Li Janet, Levy SA, Pawar R, Hartono S, Sharma K, Frost B, Chédin F, Bishop AJR (2022) Exploration and analysis of R-loop mapping data with RLBase. Nucleic Acids Research. gkac732. https://doi.org/10.1093/nar/gkac732

  2. Miller HE, Montemayor D, Abdul, J, Vines A, Levy SA, Hartono, SR, Sharma K, Frost B, Chédin F, Bishop AJR (2022) Quality-controlled R-loop meta-analysis reveals the characteristics of R-loop consensus regions. Nucleic Acids Research. gkac537. https://doi.org/10.1093/nar/gkac537

  3. Sexton C, Snyder H, Beher D, Boxer AL, Brannelly P, Brion J-P, et al. (2021) Current directions in tau research: Highlights from Tau 2020. Alzheimers Dement. doi: 10.1002/alz.12452. PMID: 34581500.

  4. Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, et al. (2022) Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica. 143:33-53. PMCID: PMC8786260.

  5. Dehkordi SK, Walker J, Sah E, Bennett E, Atrian F, Frost B, et al. (2021) Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology. Nature Aging. 1:1107-1116. doi: 10.1038/s43587-021-00142-3.

  6. Mozolewski P, Jeziorek M, Schuster CM, Bading H, Frost B, Dobrowloski R. (2021) The role of nuclear CA2+ in maintaining neuronal homeostasis and brain health. J Cell Sci., 134(8). PMCID: PMC8084578.

  7. Lohr K, Frost B, Scherzer C, Feany MB. (2020) Biotin reschues mitochondrial dysfunction and neurotoxicity in a tauopathy model. Proc Natl Acad Sci USA. 117(52). PMCID: PMC7777082.

  8. Sun W, Yan C, Frost B, Wang X, Hou C, Zeng M, Gao H, Kang Y, Liu J (2016) Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats. Scientific Reports, 6:34246. PMCID: PMC5054377.

  9. Merlo P, Frost B, Peng S, Yang Y, Park P, Feany M (2014) p53 prevents neurodegeneration by regulating synaptic genes. PNAS, 111(50):18055-60. PMCID: PMC4273405. 

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