PREPRINTS

1.     Mahoney R, Ochoa Thomas E, Ramirez P, Miller HE, Beckmann A, Zuniga G, Dobrowolski R, Frost              B (2020) Pathogenic tau causes a toxic depletion of nuclear calcium. Cell Reports, 32(2):107900.       

        PMCID: PMC7428851. 

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2.     Ochoa Thomas E, Zuniga G, Sun W, Frost B (2020) Awakening the dark side: retrotransposon         

        activation in neurodegenerative disorders. Current Opinion in Neurobiology, 61:65-72. PMID:

        32092528.

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3.     Cornelison G, Levy S, Jenson T, Frost B (2019) Tau-induced nuclear envelope invagination causes a            toxic accumulation of mRNA in Drosophila. Aging Cell, 18(1):e12847. PMCID: PMC6351838. 

4.     Sun W, Samimi H, Gamez M, Zare H, Frost B (2018) Pathogenic tau-induced piRNA depletion     

        promotes neuronal death through transposable element dysregulation in neurodegenerative

        tauopathies. Nature Neuroscience, 21(8):1038-1048. PMCID: PMC6095477.  

5.     Orr M, Sullivan C, Frost B (2017) A brief overview of tauopathy: Causes, consequences and       

        therapeutic strategies. Trends in Pharmacological Sciences, 38(7):637-648. PMCID: PMC5476494.    

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6.     Sun W, Yan C, Frost B, Wang X, Hou C, Zeng M, Gao H, Kang Y, Liu J (2016) Pomegranate extract

        decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in      

        hypothalamic paraventricular nucleus of spontaneously hypertensive rats. Scientific Reports, 6:34246.

        PMCID: PMC5054377.

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7.     Frost B (2016) Alzheimer's disease: An acquired neurodegenerative laminopathy. Nucleus,

        7(3):275-83. PMCID: PMC4991240.

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8.     Frost B, Bardai FH, Feany MB (2016) Lamin dysfunction mediates neurodegeneration in                                taupathies. Current Biology, 11;26(1):129-36. PMID: 26725200.

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9.     Frost B, Gotz J, Feany M (2015) Connecting the dots between tau dysfunction and        

        neurodegeneration. Trends in Cell Biology, 25(1):46-53. PMCID: PMC4275400.

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10.   Merlo P, Frost B, Peng S, Yang Y, Park P, Feany M (2014) p53 prevents neurodegeneration by

        regulating synaptic genes. PNAS, 111(50):18055-60. PMCID: PMC4273405.

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11.   Frost B, Hemberg M, Lewis J, Feany M (2014) Tau promotes neurodegeneration through global

        chromatin relaxation. Nature Neuroscience, 17(3):357-66. PMCID: PMC4012297.

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12.   Frost B, Diamond MI (2010) Prion-like mechanisms in neurodegenerative diseases. Nature Reviews

        Neuroscience, 11(3)155-9. PMCID: PMC3648341.

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13.   Frost B, Diamond MI (2009) The expanding realm of prion phenomena in neurodegenerative

        disease. Prion, 3(2)74-7. PMCID: PMC2712602.

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14.   Frost B, Jacks RL, Diamond MI (2009) Propagation of tau misfolding from the outside to the inside of

        a cell. J Biol Chem., 284(19):12845-52. PMCID: PMC2676015.

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15.   Frost B, Ollesch J, Wille H, Diamond MI (2009) Conformational diversity of wild-type Tau fibrils

        specified by templated conformation change. J Biol Chem., 284(6):3546-51. PMCID: PMC2635036.

SELECTED PUBLICATIONS

1.     Ramirez P, Sun W, Zuniga G, Ochoa Thomas E, DeVos S, Hyman B, Chiu G, Roy ER, Orr M, Buggia- 

        Prevot V, Ray WJ, Frost B (2021) Pathogenic tau accelerates aging-associated activation of

        transposable elements in the mouse central nervous system. bioRxiv, 

        

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2.     Beckmann A, Ramirez P, Gamez M, Ray WJ, Frost B (2021) Pathogenic tau disrupts the cellular 

        program that maintains neuronal identity. bioRxiv,