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PREPRINTS

  1. Sullivan AC, Zuniga G, Ramirez P, Fernandez R, Wang C, Li J, Davila L, Pelton K, Gomez S, Sohn C, Gonzalez E, Lopez-Cruzan M, Gonzalez DA, Parker A, Zilli E, deErausquin GA, Seshadri S, Espinoza S, Musi N, Frost B. A pilot study to investigate the safety and feasibility of antiretroviral therapy for Alzheimer's disease (ART-AD) doi: https://doi.org/10.1101/2024.02.26.24303316

  2. Ramirez P, Sun W, Kazempour SD, Zare H, Fongang B, Bieniek KF, Frost B. Nanopore-based DNA long-read sequencing analysis of the aged human brain doi: https://doi.org/10.1101/2024.02.01.578450

  3. Zuniga G, Katsumura S, De Mange J, Ramirez P, Atrian F, Masahiro M, Frost B. Pathogenic tau induces an adaptive elevation in mRNA translation rate at early stages of disease. dot: https://doi.org/10.1101/2024.02.19.581061

FROST LAB/FROST ORIGINALS

  1. Frost B (2023) Alzheimer’s disease and related tauopathies: disorders of disrupted neuronal identity. Trends in Neurosciences, in press. PMCID: PMC10528597

  2. Zuniga G, Frost B (2023) Selective neuronal vulnerability to deficits in RNA processing. Progress in Neurobiology. PMID: 37454791

  3. Beckmann A, Ramirez P, Games M, Bieniek KF, Ray WJ, Frost B (2023) Moesin is an effector of tau-induced actin over stabilization, cell cycle activation, and neurotoxicity in Alzheimer's disease. iScience, 26(3): 106152. PMID: PMC9984563

  4. Sohn C, Ma J, Ray WJ, Frost B (2023) Pathogenic tau decreases nuclear tension in cultured neurons. Frontiers in Aging, 4:1058968. PMID: PMC9901542 

  5. Ochoa E, Ramirez P, Gonzalez E, De Mange J, Ray William J, Bieniek Kevin J, Frost B (2023) Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation. Science Advances, 9(1):eabq5423. PMID: PMC9821943     

  6. Levy S, Zuniga G, Gonzalez E, Butler D, Temple S, Frost B (2022) TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy. Cell Reports Methods, 2(9):100292. PMID: PMC9500001    

  7. Schulz L, Ramirez P, Lemieux A, Gonzalez E, Thomson T, Frost B (2022) Tau-induced elevation of the activity-regulated cytoskeleton associated protein Arc1 causally mediates neurodegeneration in the adult Drosophila brain. Neuroscience, S0306-4522(22)00199-3. PMID: 35487302

  8. Zuniga G, Levy S, Ramirez P, De Mange J, Gonzalez E, Gamez M, Frost B (2022) Tau-induced deficits in nonsense-mediated mRNA decay contribute to neurodegeneration. Alzheimer's & Dementia. 19(2): 405-420. PMID: 35416419

  9. Ramirez P, Sun W, Zuniga G, Ochoa E, DeVos S, Hyman B, Chiu G, Roy ER, Orr M, Bugga-Prevot V, Ray WJ, Frost B (2022) Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system. Progress in Neurobiology, 208: 102181. PMID: 34670118.

  10. Mahoney R, Ochoa E, Ramirez P, Miller HE, Beckmann A, Zuniga G, Dobrowolski R, Frost B (2020) Pathogenic tau causes a toxic depletion of nuclear calcium. Cell Reports, 32(2):107900. PMCID: PMC7428851.

  11. Ochoa E, Zuniga G, Sun W, Frost B (2020) Awakening the dark side: retrotransposon activation in neurodegenerative disorders. Current Opinion in Neurobiology, 61:65-72. PMID: 32092528.

  12. Cornelison G, Levy S, Jenson T, Frost B (2019) Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila. Aging Cell, 18(1):el2847 PMCID: PMC6351838.

  13. Sun W, Samimi H, Gamez M, Zare H, Frost B (2018) Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies. Nature Neuroscience, 21(8): 1038-1048. PMCID: PMC6095477.

  14. Orr ME, Sullivan C, Frost B (2017) A brief overview of tauopathy: Causes, consequences and therapeutic strategies. Trends in Pharmacological Sciences, 38(7): 637-648. PMCID: PM5476494.

  15. Frost B (2016) Alzheimer's disease: An acquired neurodegenerative laminopathy. Nucleus, 7(3):275-83). PMCID: PMC4991240

  16. Frost B, Bardai FH, Feany MB (2016) Lamin dysfunction mediates neurodegeneration in tauopathies. Current Biology, 11:26(1): 129-36. PMID: 26725200.

  17. Frost B, Gotz J, Feany MB (2015) Connecting the dots between tau dysfunction and neurodegeneration. Trends in Cell Biology, 25(1):46-53). PMCID: PMC4275400.

  18. Frost B, Hemberg M, Lewis J, Feany MB (2014) Tau promotes neurodegeneration through global chromatin relaxation. Nature Neuroscience, 17(3): 357-66. PMCID: PMC4012297.

  19. Frost B, Diamond MI (2010) Prion-like mechanisms in neurodegenerative diseases. Nature Reviews Neuroscience, 11(3)155-9. PMCID: PMC3648341.

  20. Frost B, Diamond MI (2009) The expanding realm of prion phenomena in neurodegenerative disease. Prion, 3(2)74-7. PMCID: PMC2712602.

  21. Frost B, Jacks RL, Diamond MI (2009) Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem. 284(19):12845-12852. PMCID PMC2676015.

  22. Frost B, Ollesch J, Wille H, Diamond MI (2009) Conformational diversity of wild-type tau fibrils specified by templated confirmation change. J Biol Chem. 284(6):3546-3551. PMCID: PMC2635036.

COLLABORATIONS

  1. Sexton CE, Bitan G, Bowles KR, Brys M, Buée M, et al. (2024) Novel avenues of tau research. Alzheimer's & Dementia. doi: 10.1002/alz.13533. PMID: 38170841

  2. Miller HE, Montemayor D, Levy SA, Sharma K, Frost B, Bishop AJR (2023) RLSuite: An integrative R-loop bioinformatics framework. Journal of Bioinformatics and Systems Biology 6 (4): 364-378.  PMID: 38292828

  3. Miller HE, Montemayor D, Li Janet, Levy SA, Pawar R, Hartono S, Sharma K, Frost B, Chédin F, Bishop AJR (2022) Exploration and analysis of R-loop mapping data with RLBaseNucleic Acids Research. 6;51(D1):D1129-D1137. PMCID: PMC9825527    

  4. Miller HE, Montemayor D, Abdul, J, Vines A, Levy SA, Hartono, SR, Sharma K, Frost B, Chédin F, Bishop AJR (2022) Quality-controlled R-loop meta-analysis reveals the characteristics of R-loop consensus regions. Nucleic Acids Research. 50(13):7260-7286.   PMID: PMC9303298     

  5. Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, et al. (2022) Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica. 143:33-53. PMCID: PMC8786260.

  6. Sexton C, Snyder H, Beher D, Boxer AL, Brannelly P, Brion J-P, et al. (2021) Current directions in tau research: Highlights from Tau 2020. Alzheimers Dement. doi: 10.1002/alz.12452. PMID: 34581500.

  7. Dehkordi SK, Walker J, Sah E, Bennett E, Atrian F, Frost B, et al. (2021) Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology. Nature Aging. 1:1107-1116. PMID: PMC9075501

  8. Mozolewski P, Jeziorek M, Schuster CM, Bading H, Frost B, Dobrowloski R. (2021) The role of nuclear CA2+ in maintaining neuronal homeostasis and brain health. J Cell Sci., 134(8). PMCID: PMC8084578.

  9. Lohr K, Frost B, Scherzer C, Feany MB. (2020) Biotin reschues mitochondrial dysfunction and neurotoxicity in a tauopathy model. Proc Natl Acad Sci USA. 117(52). PMCID: PMC7777082.

  10. Sun W, Yan C, Frost B, Wang X, Hou C, Zeng M, Gao H, Kang Y, Liu J (2016) Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats. Scientific Reports, 6:34246. PMCID: PMC5054377.

  11. Merlo P, Frost B, Peng S, Yang Y, Park P, Feany M (2014) p53 prevents neurodegeneration by regulating synaptic genes. PNAS, 111(50):18055-60. PMCID: PMC4273405

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