NEWS

Please join us in congratulating Dr. Ramirez on the successful defense of their dissertation, Bioinformatic Analysis of Retrotransposons in the Context of Tauopathy. Thank you to all who attended, Paul's parents, sister and future brother-in-law. Special thanks to Paul's committee members for their thoughtful input and questions throughout the dissertation process: Dr. Sarah Hopp (committee member) Dr. Bernard Fongang (committee member) Dr. Evelien Bunnik (committee member) D

It's Match Week! On Monday, students found out if they matched to their residency - students found out today where they will go. Dr. Zuniga will be completing an Emergency Medicine residency with UT Health San Antonio. We know she will be an exceptional doctor and can't wait to see what she will achieve next. Best of luck! Match Day 2024 at UT Health San Antonio Long School of Medicine

This is a preprint that has not yet been reviewed. While our results are promising, this is a small trial lacking a placebo control. The study drug (3TC, aka lamivudine) would need to be tested in a large cohort of individuals and compared to a placebo control before we will know if it is an effective therapy for Alzheimer’s disease. ART-AD was an open-label phase 2 clinical trial testing the effects of 3TC in individuals with mild cognitive impairment due to suspected Alzhei

Read the publication on bioRxiv. We have previously shown that RNAs accumulate within nuclear envelope invaginations in tau transgenic Drosophila (and have now seen this in various other model systems of tauopathy as well): https://doi.org/10.1111/acel.12847 Gabbe previously reported that error-containing RNAs are not properly cleared via nonsense-mediated RNA decay in settings of tauopathy, and that such RNAs are translated into protein that also accumulates within nuclear e

Check out our new Oxford Nanopore Technologies DNA sequencing-based analysis of the aged human brain with and without tau pathology. While lead author Paulino Ramirez set off on this endeavor because we wanted to know if somatic retrotransposition is elevated in human brains harboring pathogenic forms of tau (google “Frost tau retrotransposon” for the backstory), we learned a lot of other stuff along the way. There’s a ton of data in the manuscript – a little something for

This new publication covers recent advances and new discoveries in tau research that were presented at the global Tau 2022 conference.

We are thrilled to introduce our newest team member, Melissa Soliz, who has joined us as a Research Associate in the Frost lab. Melissa brings a wealth of knowledge and expertise to our dynamic research environment. Melissa Soliz earned her Bachelor of Science degree in Biochemistry from the University of Texas at San Antonio, and her Master's degree in Immunology and Infection from the Graduate School of Biomedical Sciences at the UT Health Science Center in San Antonio. Mel

As we commemorate Dia de los Muertos, a day dedicated to honoring and remembering loved ones who have passed away, the Frost lab pays tribute to the brilliant scientists and dedicated doctors who have inspired us. We celebrate the lives and legacies of these remarkable individuals who have enriched our lives with their knowledge and dedication. As we honor their memory on Dia de los Muertos, we also celebrate the enduring impact of their work and strive to follow in their foo

The National Institute of General Medical Science blog "Biomedical Beat" showcases NIGMS-funded research and scientists, along with images and tools that help illustrate biomedical concepts and findings to the general public. Through the NIGMS, the NIH lays the foundation for advances in disease, diagnosis, treatment, and prevention. Abbey Bigler, a writer for the Biomedical Beat got a chance to catch up with Claira a few months ago to talk about her background, current event

August 15, 2023 In this review, I delve into mechanistic parallels between tauopathies, cancer, and development, and highlight the role of tau in cancer and in the developing brain. Based on these studies, I put forth a model by which pathogenic forms of tau disrupt the program that maintains terminal neuronal differentiation, driving cell cycle re-entry and consequent neuronal death. This framework presents tauopathies as conditions involving the profound toxic disruption of