NEWS

Congratulations to Dr. Morgan Thomas on the successful defense of her dissertation, "Development of an in vivo, screenable, split-luciferase based model of huntingtin multimerization." Thank you to all who attended, Morgan's parents, sister and friends. Thank you to Morgan's committee members for their thoughtful input and questions throughout the dissertation process: Dr. Kate O'Conner-Giles (committee member) Dr. Gilad Barnea (committee member) Dr. Sarah Hopp (external c

Congratulations to Joanna Sohn, undergraduate researcher in the Frost lab, who received the CurePSP Jim Atwood Neuroscience Student Fellowship!

Congratulations to Julianna Chang, undergraduate in the Frost lab, who was awarded "best poster" at Brown University Mind Brain Research Day!

Lulu Schulz presented her research at the 2026 Brown Brain Fair. The annual event brings hundreds of local children, families and community members to Brown University for a day of scientific discovery, hands-on learning and family fun. The event is organized by the Brown Brain Bee student group in collaboration with the Carney Institute for Brain Science and held in partnership with Brain Waves Rhode Island.

Her Path to Success is hosted by Sia Gullapalli - check it out!

Dr. Aly Cavalier was invited for an oral presentation at the Gerontological Society of America Meeting in Boston, MA based on her stellar abstract submission. Thanks to Aly for spreading the good word on double stranded RNAs in Alzheimer's disease and related tauopathies.

Congratulations to Dr. Aly Cavalier for her appointment to the Advancing Research Careers (ARC) program through the Brown University Carney Institute for Brain Science. ARC scholars receive career development training, structured mentoring support, and $25,000 in seed funding to support independent research projects. As an ARC scholar, Aly will be using iPSC-derived neurons and astrocytes and CRISPR gene editing to explore innate immune mechanisms of astrocyte reactivity in t

We are excited to share another new study from the lab! This project was led by Dr. Paul Ramirez, Lead Biostatistician for the Brown University Center for Alzheimer’s Disease Research. Exclusion of genomic “dark regions” from traditional DNA sequencing analysis limits our understanding of human biology and disease. These regions are highly repetitive, structurally complex, and lacking in the standard GRCh38 human reference genome. Dark regions include low-complexity microsate

We are excited to share the culmination of critical discussions from the Fall 2024 Alzheimer's Association Research Roundtable. The Research Roundtable serves as a forum for scientists and industry leaders to address key areas in the field, including drug development, clinical trials, and emerging research frameworks. This particular Roundtable, organized by Bess Frost, Hartmuth Kolb, Christopher Weber and committee members from Eisai Co., Ltd., Johnson & Johnson, Eli Lilly a

Cells detect and respond to mechanical forces that shape their function and survival through a process termed “mechanotransduction.” While well studied outside of the brain, little is known regarding neuronal mechanotransduction despite exposure of the brain to vascular flow, movement, injury, and disease. This study was an outgrowth of our original finding that tau destabilizes the nucleoskeleton in neurons and drives nuclear envelope blebbing and invagination (2016 Frost et