The Frost laboratory studies fundamental processes in cell biology that drive age-related neurodegenerative disorders. We employ a multi-system approach to rapidly identify, test, and validate hypotheses that are relevant to human disease. Early discovery takes place in Drosophila, a model organism that is well suited for investigating issues of causality in disease processes. To determine if our studies are relevant to human disease, we complement Drosophila work with comparative analyses in mouse and postmortem human brain.  

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