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Frost lab publishes in Cell Reports

Nuclear calcium (Ca2+) is a major mediator of communication between synapses and nuclei and is critical for CREB-dependent gene expression. Mahoney, Ochoa Thomas and colleagues identify nuclear Ca2+ depletion as a pathomechanism connecting disease-associated forms of tau to neuronal death, adding an important dimension to the long-standing Ca2+ hypothesis of Alzheimer’s disease. This work was performed in collaboration with Dr. Radek Dobrowolski, and was funded by the American Federation for Aging Research and NIH.

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