The Frost lab received an R01 from the National Institute on Aging to study the effects of tau on nuclear architecture and RNA handling. We are currently recruiting a postdoctoral fellow for this project.
The Alzheimer’s Drug Discovery Foundation awarded Gabbe with a Young Investigator Scholarship to travel to the 13th Annual Drug Discovery for Neurodegeneration Conference in Long Beach, California. The course focuses on translating research into drug development.
Garrett Cornelison reports that pathological tau causes an accumulation of polyadenylated RNA within nuclear envelope invaginations in a Drosophila model of tauopathy. Genetic and pharmacologic approaches to reduce RNA export suppress tau-induced neurotoxicity.